Mazdutide

Buy Mazdutide Peptide | Trusted Dual GLP-1R/GCGR Agonist Research Compound | PrimaLab Peptide

Mazdutide (also known by the research designations IBI-362, LY3305677, and OXM-3) is a synthetic dual agonist research peptide simultaneously targeting two metabolic receptors: the GLP-1 receptor (GLP-1R) and the glucagon receptor (GCGR). Researchers who buy Mazdutide peptide use it to investigate the combined metabolic effects of dual GLP-1R and GCGR co-activation — exploring how simultaneous engagement of these two distinct receptor pathways affects insulin secretion, glucagon dynamics, hepatic glucose production, energy expenditure, and body weight regulation in controlled research models. PrimaLab Peptide supplies research-grade Mazdutide at 99%+ purity, independently verified by Janoshik Analytical, with a full batch-specific Certificate of Analysis included with every order.

What Is Mazdutide?

Mazdutide is a synthetic acylated peptide designed as a dual agonist of GLP-1R and GCGR — two G protein-coupled receptors (GPCRs) with complementary but distinct roles in metabolic regulation. The compound carries multiple research designations: IBI-362 (Innovent Biologics development code), LY3305677 (Eli Lilly research designation), and OXM-3 (reflecting its structural relationship to oxyntomodulin — an endogenous peptide that naturally co-activates GLP-1R and GCGR).

The full amino acid sequence of Mazdutide is:

His-Aib-Gln-Gly-Thr-Phe-Thr-Ser-Asp-Tyr-Ser-Lys-Tyr-Leu-Asp-Glu-Lys-Lys-Ala-Lys(AEEA-AEEA-γGlu-Eicosanedioic acid)-Glu-Phe-Val-Glu-Trp-Leu-Leu-Glu-Gly-Gly-Pro-Ser-Ser-Gly-NH₂

CAS: 2259884-03-0 | Molecular formula: C₂₁₀H₃₂₂N₄₆O₆₇ | MW: 4563.06 g/mol

The sequence includes an Aib (alpha-aminoisobutyric acid) substitution at position 2 for improved metabolic stability, a fatty acid acylation at Lys20 (via AEEA-AEEA-γGlu linker attached to eicosanedioic acid) enabling albumin binding for extended half-life, and structural elements derived from the oxyntomodulin/GLP-1 peptide family. These modifications collectively produce a research compound designed for sustained dual GLP-1R/GCGR co-activation with extended circulating half-life compared to native oxyntomodulin.

A comprehensive overview of the GLP-1R and GCGR receptor biology relevant to Mazdutide research is available through published PubMed research on dual GLP-1/glucagon receptor agonism.

Mazdutide Research Applications

Mazdutide’s dual GLP-1R/GCGR mechanism distinguishes it from single-receptor GLP-1 agonists such as Semaglutide and from dual GIP/GLP-1 agonists such as Tirzepatide, providing researchers with a distinct pharmacological tool for studying the specific contribution of combined GLP-1R and GCGR co-activation to metabolic outcomes. Published research has examined Mazdutide in the following areas:

• Dual receptor co-activation research: The primary research interest in Mazdutide is its simultaneous GLP-1R and GCGR agonism, allowing researchers to study how co-activation of these two receptors produces metabolic effects distinct from single-receptor GLP-1 agonism — particularly in the context of hepatic glucose production, energy expenditure, and adipose tissue metabolism
• Hepatic glucose and lipid metabolism research: GCGR activation increases hepatic glucose production and fatty acid oxidation in research models. When combined with GLP-1R-mediated insulin secretion stimulation, researchers study the net metabolic balance of dual GLP-1R/GCGR co-activation on hepatic glucose and lipid metabolism
• Energy expenditure research: Glucagon receptor activation is associated with increased energy expenditure and thermogenesis in research models. Mazdutide research examines whether dual GLP-1R/GCGR agonism produces additive effects on energy expenditure compared to GLP-1R agonism alone
• Body weight and adiposity research: Combined GLP-1R and GCGR activation has been studied for effects on body weight regulation and adipose tissue mass in preclinical research models
• Comparative multi-receptor agonist research: Mazdutide is frequently studied in comparative research alongside Semaglutide (GLP-1R single agonist), Tirzepatide (GIP/GLP-1R dual agonist), and Retatrutide (GLP-1R/GIP/GCGR triple agonist) to systematically investigate the metabolic contributions of each receptor pathway combination
• Glucagon biology research: As a GCGR agonist component, Mazdutide provides a research tool for studying glucagon receptor-mediated effects in the context of concurrent GLP-1R activation — relevant to research on alpha-cell/beta-cell crosstalk and glucagon physiology in metabolic research models

Mazdutide in the Multi-Receptor Agonist Research Landscape

Understanding where Mazdutide sits in the evolving multi-receptor agonist research landscape is important for study design:

• Semaglutide: Single GLP-1R agonist — the reference comparator for GLP-1R biology research
• Cagrilitide + Semaglutide (Cagri+Sema Blend): Amylin receptor + GLP-1R dual pathway
• Tirzepatide: GIP receptor + GLP-1R dual agonist
• Mazdutide (this product): GLP-1R + glucagon receptor (GCGR) dual agonist — distinct from Tirzepatide in replacing GIP receptor engagement with glucagon receptor engagement
• Retatrutide: GLP-1R + GIP receptor + GCGR triple agonist — the most comprehensive multi-receptor agonist in PrimaLab Peptide’s metabolic research catalog

This mechanistic diversity across the metabolic peptide research catalog allows researchers to systematically study the independent and combined contributions of GLP-1R, GIP receptor, amylin receptor, and GCGR pathways to metabolic regulation. Browse the full Metabolic Peptides category.

Purity & Third-Party Testing

Every batch of Mazdutide supplied by PrimaLab Peptide is independently tested by Janoshik Analytical at 99%+ purity via HPLC and mass spectrometry identity confirmation (CAS: 2259884-03-0, MW: 4563.06 g/mol, C₂₁₀H₃₂₂N₄₆O₆₇). The batch-specific COA is included with every order. Always review the current batch COA — match the vial label, batch number, and COA report before use in any research protocol. Do not rely on the product listing alone.

Storage & Handling

• Storage (sealed, lyophilized): −20°C, sealed, dry, away from light. Keep vials sealed until research use begins
• Freeze-thaw cycles: Minimise. Do not repeatedly open and re-seal the same vial. Aliquot into single-use volumes when your protocol allows
• Reconstitution: Reconstitute with sterile Bacteriostatic Water (BAC Water) per your laboratory SOP. Record the solvent, date, time, and storage temperature after reconstitution
• Post-reconstitution: Storage requirements depend on the reconstitution solvent and your specific protocol. Follow your laboratory SOP for peptide solution storage
• Damaged or unlabelled vials: Do not use damaged or unlabelled vials. Log each batch into your laboratory inventory on receipt
• Qualified handling: Mazdutide requires trained handling in a qualified research setting. It is not for personal use, injection, food use, or clinical use

Product Specifications

Product Name	Mazdutide
Synonyms	IBI-362, LY3305677, OXM-3
CAS Number	2259884-03-0
Mechanism	Dual GLP-1R and GCGR agonist
Sequence	His-Aib-Gln-Gly-Thr-Phe-Thr-Ser-Asp-Tyr-Ser-Lys-Tyr-Leu-Asp-Glu-Lys-Lys-Ala-Lys(AEEA-AEEA-γGlu-Eicosanedioic acid)-Glu-Phe-Val-Glu-Trp-Leu-Leu-Glu-Gly-Gly-Pro-Ser-Ser-Gly-NH₂
Molecular Formula	C₂₁₀H₃₂₂N₄₆O₆₇
Molecular Weight	4563.06 g/mol
Purity	99%+ (Janoshik HPLC + Mass Spectrometry verified)
Form	Lyophilized powder
Storage	−20°C, sealed, dry, away from light
Reconstitution	Bacteriostatic Water (BAC Water)
Testing Lab	Janoshik Analytical (independent third-party)
COA	Batch-specific — included with every order
Intended Use	Research use only — not for human use

Frequently Asked Questions — Mazdutide Peptide

What is Mazdutide used for in research?

Researchers who buy Mazdutide peptide use it to investigate dual GLP-1R and GCGR co-activation effects on hepatic glucose and lipid metabolism, energy expenditure regulation, glucagon biology in the context of concurrent GLP-1R activation, body weight and adiposity research, and comparative multi-receptor agonist metabolic research alongside Semaglutide, Tirzepatide, and Retatrutide. Published research is available on PubMed.

What is the difference between Mazdutide and Tirzepatide?

Both are dual receptor agonists but target different receptor combinations. Tirzepatide is a dual GIP receptor + GLP-1R agonist — it combines GIP receptor engagement (glucose-dependent insulinotropic polypeptide receptor) with GLP-1R activation. Mazdutide is a dual GLP-1R + GCGR agonist — it combines glucagon receptor engagement with GLP-1R activation instead. The replacement of GIP receptor engagement with glucagon receptor engagement produces a distinct metabolic receptor co-activation profile, particularly regarding hepatic glucose production and energy expenditure effects.

How does Mazdutide compare to Retatrutide?

Retatrutide is a triple agonist targeting GLP-1R + GIP receptor + GCGR simultaneously. Mazdutide targets only GLP-1R + GCGR (dual agonist), without GIP receptor engagement. This makes Mazdutide a useful research tool for isolating the specific contribution of GLP-1R + GCGR co-activation from the full triple agonist profile of Retatrutide in comparative metabolic research designs.

Is Mazdutide from PrimaLab Peptide independently tested?

Yes. Every batch is independently verified by Janoshik Analytical at 99%+ purity via HPLC and mass spectrometry identity confirmation (CAS: 2259884-03-0, MW: 4563.06 g/mol). The batch-specific COA is included with every order. Always match the vial label and batch number to the COA report before use in any research protocol.

What is the significance of Mazdutide’s acylation in research?

The fatty acid acylation at Lys20 of Mazdutide (via the AEEA-AEEA-γGlu linker connected to eicosanedioic acid) enables albumin binding in research systems, extending the compound’s circulating half-life compared to non-acylated oxyntomodulin. This extended half-life is research-relevant because it allows sustained dual GLP-1R/GCGR activation over longer experimental windows without repeated addition to research systems — an important practical consideration for in vitro and preclinical research protocol design.

What peptides are commonly studied alongside Mazdutide?

Researchers buying Mazdutide peptide for metabolic research frequently explore the full range of GLP-1 class research compounds from PrimaLab Peptide for comparative multi-receptor agonist studies including Semaglutide (GLP-1R single agonist reference), Tirzepatide (GIP/GLP-1R dual agonist), Retatrutide (GLP-1R/GIP/GCGR triple agonist), and Cagri+Sema Blend (amylin/GLP-1R dual pathway). Browse the complete Metabolic Peptides category.

Related Research Peptides

Researchers buying Mazdutide peptide for metabolic and GLP-1 class research frequently explore:

• Semaglutide — GLP-1R single agonist reference comparator for metabolic research
• Tirzepatide — dual GIP receptor + GLP-1R agonist for comparative dual agonist research
• Retatrutide — triple GLP-1R + GIP + GCGR agonist for comprehensive multi-receptor research
• Cagrilitide — long-acting amylin analogue for amylin/GLP-1R co-agonism research
• AOD9604 — modified GH fragment for complementary fat metabolism research
• 5-Amino-1MQ — NNMT inhibitor for complementary metabolic pathway research

Browse our complete Metabolic Peptides category. Bulk researchers can apply for discounted rates through our Wholesale Portal. Reconstitute with BAC Water, available in our Accessories & Reconstitution Supplies section.

⚠️ For laboratory research use only. Not for human use. Not a medicine. Not for treatment, diagnosis, or prevention of any condition. Not for injection, food use, or clinical use. All buyers must comply with applicable local regulations. Researchers are solely responsible for compliance with all applicable national and international regulations governing the purchase, storage, and use of research compounds.